منابع مشابه
Protein kinase A anchoring.
Specificity is perhaps the most enigmatic property of hormonemediated signaling pathways, especially when one considers that more than 30 hormones employ the ubiquitous second messengers, Ca, phospholipid, or cAMP, to relay messages from the cell membrane to intracellular effectors. In most cases the net signaling effect is to activate protein kinases or phosphoprotein phosphatases, which, in t...
متن کاملA A-Kinase Anchoring Protein (AKAP)
Classical physiological experiments identified cAMP as a diffusible intracellular secondary messenger capable of activating cAMP-dependent protein kinase (PKA). These studies defined hormoneand location-specific patterns of PKA activation, suggesting that PKA signaling was compartmentalized. For example, in perfused rat cardiomyocytes, adrenergic stimulation selectively activates a pool of PKA ...
متن کاملA-kinase anchoring proteins: protein kinase A and beyond.
Compartmentalization of kinases and phosphatases is a key determinant in the specificity of second messenger mediated signaling events. Localization of the cAMP-dependent protein kinase (PKA) and other signaling enzymes is mediated by interaction with A-kinase anchoring proteins (AKAPs). In the past year there have been many advances in our understanding of AKAPs, particularly in the field of t...
متن کاملEzrin is a cyclic AMP-dependent protein kinase anchoring protein.
cAMP-dependent protein kinase (A-kinase) anchoring proteins (AKAPs) are responsible for the subcellular sequestration of the type II A-kinase. Previously, we identified a 78 kDa AKAP which was enriched in gastric parietal cells. We have now purified the 78 kDa AKAP to homogeneity from gastric fundic mucosal supernates using type II A-kinase regulatory subunit (RII) affinity chromatography. The ...
متن کاملCypher/ZASP is a novel A-kinase anchoring protein.
PKA signaling is important for the post-translational modification of proteins, especially those in cardiomyocytes involved in cardiac excitation-contraction coupling. PKA activity is spatially and temporally regulated through compartmentalization by protein kinase A anchoring proteins. Cypher/ZASP, a member of PDZ-LIM domain protein family, is a cytoskeletal protein that forms multiprotein com...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 1997
ISSN: 0021-9258
DOI: 10.1074/jbc.272.20.12881